Postdoctoral in Modeling and Regulation of Bioproduction Royal Institute of Technology, Department of Regulatory Technology

Postdoctoral in modeling and regulation of bioproduction

 

Royal Institute of Technology,

 

KTH is one of Europe's leading technical universities and an important arena for knowledge development. As Sweden's largest university of technical research and education, we gather students, researchers and faculty from around the world. Our research and education covers both natural sciences and all branches of technology as well as architecture, industrial economics, social planning, technical history and philosophy.

 

Department of Regulatory Technologyconducts research in system identification, control technology, machine learning and optimization of dynamic systems with applications in autonomous systems, network-based systems, process control, bioprocess management, robotics and system security. The staff has an international background and the working language is English. The department is internationally well established and participates in many European and national research centers and projects. Industrial projects are conducted in cooperation with ABB Corporate Research, ABB Process Automation, BillerudKorsnäs, Ericsson Research and Scania. We have a large academic network and collaborate with researchers at MIT, UC Berkeley, Stanford University, TU Eindhoven and Université de Lyon. Control technology and automation at KTH was ranked 12th in the world in recent ARWU Shanghai ranking.

 

KTH offers an attractive working environment, generous salary and other employment benefits.

 

project Description

 

Biopharma is a very active and profitable industry where production has evolved from being based on bacterial systems for animal cell-based systems. So far, most of all production has taken place via fat batch, but many of the dominant Pharma / Biotech companies today explore the possibilities of continuous processes, ie processes based on a perfusion culture where medium is continuously supplied. These processes have the potential to provide higher yields, be cheaper and more flexible.

 

Production under such conditions requires that the process be regulated via feedback and this in turn requires relevant process models. Through several projects, the Department of Regulatory Technology at KTH has begun to build a business around this area with the aim of creating a long-term world-leading environment for modeling and regulation of continuous bioproduction. Currently, the group consists of two professors with specialization in computer-driven modeling and regulation and a postdoctoral researcher working in the VINNOVA sponsored project "Smart feed design for biopharmaceutical production" (SmartFD), where we work with the School of Biotechnology at KTH, the world leader in perfusion, as well as with GE Healthcare and Cobra Biologics as industry partners.

 

The service in question is linked to the new research center Center for Advanced BioProduction, AdBIOPRO, led by KTH, and is run in collaboration with Lund University and Karolinska University Hospital and seven Swedish companies in the biopharmaceutical / biotech area. The center focuses on bioproduction based on animal and human cells with the aim of responding to industry needs for the forthcoming paradigm shift towards continuous processes. The ambition is to become world leader in the field.

 

The project involves model-based optimization and regulation of media and processes. It includes development of methods for mechanical macroscopic metabolic models, parameter estimation and experimental design for identification of such models, as well as optimization and feedback of cell metabolism through media delivery. The project is conducted in close collaboration with the School of Biotechnology, which has extensive experimental facilities and industry partners . The ultimate goal is to verify the developed methods in the industrial environment. There will also be close collaboration with the SmartFD project.

 

In summary, the project focuses on the modeling of bioprocesses and algorithm development for data-driven modeling, optimization and regulation, where industrial relevance will be ensured through attempts in laboratory and industrial environments.

 

We are looking for candidates with background from modeling of response networks, parameter estimation, as well as off and on-line optimization (model predictive regulation), preferably with experience from bioproduction.

 

qualifications

 

Applicants must have a doctorate or be close to the Department of Electrical, Chemical or Biotechnology. Applicants should have a strong background in at least one of the following areas: modeling of bioprocessen, system identification, or model predictive regulation. The selected candidate should have excellent research and publishing results. Well-developed analytical skills and skills in problem solving are a requirement. We are looking for a highly motivated candidate who can work independently. Good knowledge of English in speech and writing is necessary to publish and present research results.

 

Union representatives

You will find contact information for union representatives on the KTH website . 

 

Application

You apply through KTH's recruitment tool. You as the applicant have the primary responsibility for your application being complete when it is submitted. Your complete application must be KTH at the latest by the closing date for the application period.

 

The application must contain the following documents:

  1. Full CV including all your relevant academic and professional achievements, experiences and knowledge

  2. Copy of diploma from your previous university studies

  3. Brief statement: What are your academic interests, how do they relate to your previous studies and future goals, max 2 pages long

  4. Publication list and copies of two representative publications or technical reports no longer than 10 pages each. For longer documents (eg dissertations), attach a summary (abstract) and a web link to the full text.

  5. TESTIMONIAL

  6. Contact information for two reference persons

 

Other

The employment is limited to 1 year with the possibility of renewal for another 1 year.

 

We discourage direct contact with staffing and recruitment companies as well as sales adverts.

 

Type of employment

Fixed-term employment longer than 6 months

Extent of employment

Full-time

Access

By agreement, preferably as soon as possible

Salary

Monthly Salary

Number of vacancies

1

employment rate

100%

place

Stockholm

County

Stockholm County

Country

Sweden

References

E-2017-1311

Contact

  • Håkan Hjalmarsson, professor, hakan.hjalmarsson@ee.kth.se, +46 8 790 42 57

  • Elling W Jacobsen, Professor, jacobsen@kth.se, +46 8 790 73 25

  • Mikael Visén, Human Resources Administrator, Rekrytering@ee.kth.se, +46 8 790 84 89

Published

2017-11-22

Application deadline

2018-01-15

 


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